test on 14/9/13

TEST FOR FINAL YEARS (14/9/13)

SUPERIOR VENAE CAVA SYNDROME (7 MARKS)
TARGETED THERAPY IN LUNG CANCER(7 MARKS)
MOLECULAR BASICS OF LUNG CANCER (7 MARKS)
SBRT IN LUNG CANCER (7 MARKS)
STAGING OF LUNG CANCER(7 MARKS)
NATURAL HISTORY AND PRESENTATION OF LUNG CANCER(7 MARKS)
MANAGEMENT OF STAGE III B LUNG CANCER( 7 MARKS)
SCREENING AND WORKUP OF LUNG CANCER(7 MARKS)
SMALL CELL CARCINOMA LUNG( 7 MARKS)
NORMAL TISSUE EFFECT OF LUNG AND HEART ( 7 MARKS)
NOTE ON LUNG CANCER AND CHEMOTHERAPY(15 MARKS)
INDICATION OF RADIATION IN LUNG CANCER (15 MARKS

again we have done it!!!!

good variety of papers from cancer institute, in this AROI. discuss ur paper in one or two pages in your log book. also discuss any other guest lecture, which inspired u.......... this is for this week.

RTOG article

this week article is RTOG 90-03 trial. Search the net, download the article and write.

article for this week

to download ... click here

for log book writin,- this week

what is the above chart known as?

how you will read this chart?

comment on this chart and give your conclusion!

The above chart had been taken from page 28 of the cochrane review article, download link- click here

article of this week

click here
this is a link from the ASCO educational book 2012, hope this will be useful.
thanks for u people who have read and wrote the previous article in your log book, continue the same

journal club article for this week

click here 

test questions for cancer etiology

TEST ON ETIOLOGY OF CANCER
What are the relevant points you will ask the patient, for the history of tobacco usage? (3marks)
What are the carcinogens in tobacco? (3marks)
What are the cancers directly linked to tobacco usage? (3marks)
What is Li-fraumeni syndrome? (3marks)
What are the cancer susceptibility syndromes associated with gastro intestinal malignancies? (3marks)
What is BRCA1 and BRCA2 ? (3marks)
A note on hereditary breast cancer ? (3marks)
What are AIDS defining malignancy? What are AIDS associated malignancy? (3marks)
What are the cancers caused by Ebstein Barr Virus? (2marks)
What is the mechanism of carcinogenesis of HPV? (3marks)
HPV vaccination? (3marks)
What are the chronic inflammatory conditions associated with malignancy? (3marks)
Cahan’s criteria? (3marks)
Radiation carcinogenesis? (3marks)
What is Xeroderma pigmentosa? (3marks)
Prognostic markers for carcinoma cervix? (3marks)
Prognostic markers for carcinoma lung? (3marks)

Hodgkin's Indication of Radiation

click here

NSABP timeline

one of the favorite question of my Professor is name some NSABP trials?

comet assay

click here to download the pdf

tyrosine kinase inhibitors

two good articles on tyrosine kinase inhibitors.

click here and also here

Metastatic inguinal lymphadenopathy

good case report on metastatic inguinal lymphadenopathy with primary undetected.

click here

BYSTANDER EFFECT

a good article on bystander effect

CLICK HERE

Endocrine Disrupting chemicals

click here to download

Endocrine Disruptors

click here to download

Diagnostic and Therapeutic Applications of Epigenetics

Epigenetic abnormalities, such as aberrant methylation of CpG islands, are inherited over cell

divisions, and play important roles in carcinogenesis. Aberrant methylation ofCpGislands specific

to tumor cells can be used as a marker to detect cancer cells or cancer-derived DNA, taking

advantage of the high sensitivity of methods to detect aberrant methylation. Methylations of

specific genes or methylation patterns of groups of genes were found to be associated with

responses to chemotherapeutics and prognosis. Methylation in non-cancerous tissues is now

attracting attention as a tumor risk marker, and is emerging as a target for cancer prevention.

Epigenetic alterations are potentially reversible. The use ofDNAdemethylating agents has turned

out to be effective for hematological malignancies, and is being tested in solid tumors. Histone

deacetylase inhibitors and methods for gene-specific epigenetic modification are being

developed. Application of epigenetics to cancer diagnostics and therapeutics, and possibly to

cancer prevention, is coming into clinics.

for more details click here

Epigenetics in cancer

Epigenetic mechanisms are essential for normal development and

maintenance of tissue-specific gene expression patterns in mammals.

Disruption of epigenetic processes can lead to altered gene

function and malignant cellular transformation. Global changes

in the epigenetic landscape are a hallmark of cancer. The initiation

and progression of cancer, traditionally seen as a genetic

disease, is now realized to involve epigenetic abnormalities along

with genetic alterations. Recent advancements in the rapidly

evolving field of cancer epigenetics have shown extensive reprogramming

of every component of the epigenetic machinery in

cancer including DNA methylation, histone modifications, nucleosome

positioning and non-coding RNAs, specifically microRNA

expression. The reversible nature of epigenetic aberrations has

led to the emergence of the promising field of epigenetic therapy,

which is already making progress with the recent FDA approval

of three epigenetic drugs for cancer treatment. In this review, we

discuss the current understanding of alterations in the epigenetic

landscape that occur in cancer compared with normal cells, the

roles of these changes in cancer initiation and progression, including

the cancer stem cell model, and the potential use of this knowledge

in designing more effective treatment strategies.

full article- click here

CME on head and neck cancer at JIPMER

for furthur details

Click here

High grade Glioma RPA

Recursive partition analysis for High grade glioma's ans survival